Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats
نویسندگان
چکیده
BACKGROUND Cognitive impairment occurs in diabetes mellitus. Teucrium polium L. (Lamiaceae) has been used in folk medicine to improve mental performance. Here we hypothesized that chronic treatment with an aqueous extract of Teucrium polium (100, 200 and 400 mg/kg, p.o.) would have an effect on passive avoidance learning (PAL) and memory in control and streptozocin-induced diabetic rats. MATERIAL/METHODS Treatments were begun at the onset of hyperglycemia, and PAL was assessed 30 days later. A retention test was performed 24 h (hours) after training. After PAL and memory assessment, animals were weighed and blood samples were drawn for plasma glucose measurement. RESULTS Diabetes caused impairment in acquisition of PAL and retrieval of memory. Teucrium polium treatment (200 and 400 mg/kg) improved learning and memory in control rats and reversed learning and memory deficits in diabetic rats. The 100 mg/kg dose did not affect cognitive function. Teucrium polium treatment partially improved the reduced body weight and hyperglycemia of treated diabetic rats, although the differences were not significant compared to non-treated diabetic rats. CONCLUSIONS These results show that Teucrium polium prevented the deleterious effects of diabetes on PAL and memory. Antioxidant, anticholinesterase and hypoglycemic effects of Teucrium may be involved in the obtained effects. Therefore, Teucrium polium appears to be a promising candidate for memory improvement in diabetes, but this needs confirmation by future clinical studies.
منابع مشابه
Comment on: Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats
We read with great interest the article by Hasanein and colleagues in the Medical Science Monitor Journal, entitled “Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats” [1]. They aimed to investigate passive avoidance learning and memory in control and streptozocin-induced diabetic rats treated with an aqueous extract of Teucrium polium. Impairment in acquisit...
متن کاملBeneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats
Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). G...
متن کاملProtective effect of hydroalcoholic extract of Teucrium polium on diabetes-induced testicular damage and serum testosterone concentration
BACKGROUND Diabetes has an adverse effect on spermatogenesis by rising oxidative stress. OBJECTIVE The aim of this study was to investigate the effect of Teucrium Polium extract administration on spermatogenesis and testicular structure in diabetic rats induced with Streptozotocin. MATERIALS AND METHODS 32 male Wistar rats were randomly divided into four groups (n=8/each): control group, di...
متن کاملThe Effect of Teucrium Polium Boiled Extract in Diabetic Rats
OBJECTIVE: In traditional medicaments, Teucrium Polium is used as anti-fungal, antibacterial, anti-inflammatory and antidiabetic. Modern researches have shown that use of T. polium in vitro leads to decrease in fatty acids. To confirm the anti-diabetic evidences of Teucrium polium this survey was done to evaluate the effect of boiled aqueous extract of T. polium on serum lipids, body weight and...
متن کاملAdministration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress
Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-trea...
متن کامل